منابع مشابه
Modeling and simulation of ion channels.
Ion channels are formed by specific proteins embedded in the cell membrane and provide pathways for fast and controlled flow of selected ions through the channels. Ion channels generate action potentials in nerves, muscles and other excitable cells, and are the basis of all movement, sensation and thought processes in living beings. While the functional properties of ion channels are well known...
متن کاملStochastic Modeling and Simulation of Ion Transport through Channels
Abstract Ion channels are of major interest and form an area of intensive research in the fields of biophysics and medicine, since they control many vital physiological functions. The aim of this work is to propose a fully stochastic model describing the main characteristics of a multiple channel system, in which ion movement is coupled with a Poisson–Nernst–Planck equation. Exclusion forces ar...
متن کاملModeling of Ion Channels
Modeling of biological ion channels has a long history, going back more then 100 yr (Hille 1984). In the old, premolecular biology era, interpretation of these simple models provided the primary source of information about channel structure. As molecular biology and, now, x-ray diffraction have provided direct information about structure, modeling has been reduced to playing more of a secondary...
متن کاملModeling of voltage-gated ion channels Modeling of voltage-gated ion channels
The recent determination of several crystal structures of voltage-gated ion channels has catalyzed computational efforts of studying these remarkable molecular machines that are able to conduct ions across biological membranes at extremely high rates without compromising the ion selectivity. Starting from the open crystal structures, we have studied the gating mechanism of these channels by mol...
متن کاملModeling ion channels: Past, present, and future
Ion channels are membrane-bound enzymes whose catalytic sites are ion-conducting pores that open and close (gate) in response to specific environmental stimuli. Ion channels are important contributors to cell signaling and homeostasis. Our current understanding of gating is the product of 60 plus years of voltage-clamp recording augmented by intervention in the form of environmental, chemical, ...
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ژورنال
عنوان ژورنال: Chemical Reviews
سال: 2012
ISSN: 0009-2665,1520-6890
DOI: 10.1021/cr3002609